Information

Name - Tramadol the generic form of Ultram, is an analgesic utilized to treat or forbid pain. Chemical Name: hydrochloride is (±)cis-2-[(dimethylamino)methyl]-1-(3-methoxyphenyl) cyclohexanol hydrochloride. Chemical Information: the molecular weight of tramadol hydrochloride is 299.8. Tramadol hydrochloride is a white, acrid, crystal-like, and non-odorous powder. It is easily dissolved in water and ethanol and possesses a pKa of 9.41. The n-octanol and water log partition coefficient or logP is 1.35 with a pH level of 7. ULTRAM pills contain 50 mg of tramadol hydrochloride and are white in hue. Inactive components of the pill include corn starch, hypromellose, lactose, magnesium stearate, titanium dioxide, and wax.

Drug Interactions - In vitro studies suggest that Tramadol (Ultram) is not likely to inhibit the CYP3A4-mediated metabolism of other medications when Tramadol (Ultram) is administered concomitantly at therapeutic doses. Tramadol (Ultram) does not appear to generate its own metabolism in people, since observed maximal plasma concentrations after continued oral doses are higher than expected based on single-dose data. Tramadol (Ultram) is a minor facilitator of certain drug metabolism pathways detected in animals.

Tramadol Storage - Keep at 25 degrees C or 77 degrees F; with a permissable range of 15 - 30 degrees C or 59 - 86 degrees F.

Use with Carbamazepine - Patients using carbamazepine might experience a dramatically lowered analgesic effect of ULTRAM. Since carbamazepine elevates Tramadol metabolism and since the incidence of seizure is linked with Tramadol, use of Ultram in conjunction with carbamazepine is not advised.

Utilization of Quinidine - Tramadol (Ultram) involves metabolism to M1 through CYP2D6. Quinidine is a discriminating inhibitor of that isoenzyme, hence using quinidine in conjunction with ULTRAM leads to greater levels of Tramadol (Ultram) and lowered levels of M1. The clinical outcomes of these results are not known. In vitro drug interaction research in human liver microsomes shows that Tramadol (Ultram) does not impact the metabolism of quinidine.

Utilization with Inhibitors of CYP2D6 - In vitro medication interaction research in human liver microsomes shows that use in conjunction with CYP2D6 inhibitors like fluoxetine, paroxetine, and amitriptyline may lead to certain inhibition of the metabolic process of Tramadol (Ultram).

Use with Cimetidine - Using ULTRAM in conjunction with cimetidine does not produce clinically relevant alterations in Tramadol (Ultram) pharmacokinetics. Thus, no modification of the ULTRAM dosage administration is advised.

Use with MAO Inhibitors - Because of interference with the mechanics of detoxification, interactions occurring with MAO Inhibitors have been documented with certain centrally acting medications (refer to WARNINGS, Use with MAO Inhibitors).

Use with Digoxin and Warfarin - After-market assessment has disclosed unusual incidence of digoxin toxicity and altered reaction of warfarin, including higher prothrombin incidence.

Children - There is no explicit data on the connection between age and effects of Tramadol (Ultram) in patients younger than 16.

Precautions for Taking Tramadol - It is essential to mention that Tramadol is a narcotic and thus its use may become habitual. It is totally essential that you use this drug only as prescribed by your physician. Never use more than the suggested dose. In addition, you ought to inform your physician if you suffer from other medical issues like kidney or liver disease. Tramadol frequently produces sleepiness, thus you ought to avoid operating a vehicle until you are aware of how it affects you. Under no circumstance should you consume alcohol when using Tramadol as well. Inform your physician of any different drugs or treatments you are using, including homeopathic substances like St. John’s Wort.

Tramadol has demonstrated its effectiveness for chronic pain sufferers who use this drug. It does appear to possess certain side effects, including anxiety, chills or perspiration, dry mouth, rash, mood swings, heartburn, constipation, somnolence, and so on, yet these are ordinarily not sufficiently serious to justify suspending use of the drug. If you are pondering use of Tramadol or have currently been prescribed its use by your physician, make sure to adhere strictly to the guidelines.